Our ultimate B vitamins blood test panel - includes an extended B12 test panel with Fedosov Factor which is the novel vitamin B12 wellbeing score, as well as vitamins B1 B2 and B6.
About this Panel
Nutris Aquasorb is our most comprehensive nutrient deficiency test. It tests the levels of vitamins B1, B2, B6, folate, serum B12, Active B12 plus homocysteine, methylmalonic acid and includes Fedosov Factor.
Water-soluble vitamins have a wide array of functions. With the notable exception of B12, only limited quantities of water-soluble vitamins are stored within our bodies. To facilitate absorption, vitamin-specific membrane transport processes have evolved within the small intestine.
Vitamin B1 is required for the metabolism of glucose, amino acids and lipids. Deficiency is linked to tiredness, weight loss and irritability.
Vitamin B2 (also known as riboflavin) is essential for your body to produce energy and support numerous other metabolic pathways. Deficiency of this vitamin has a negative impact on vitamins B3, B6 and folate status.
Vitamin B6 refers to a group of compounds which are interconverted in your body. We measure the active form of the vitamin pyridoxal5'-phosphate, which serves as a coenzyme for more than 100 essential enzyme reactions.
Folate (Vitamin B9) is naturally present in many foods such as vegetables, fruits and grains. It is needed for the body to produce DNA, which is why it is so critical during pregnancy. Along with vitamin B12, folate is responsible for helping maintain a healthy nervous system.
Vitamin B12 is responsible for a number of important functions in the body including healthy nerves and red blood cells. The current convention, followed by most GPs, is to use Total B12 as the first-line screen for deficiency.
Active B12 (holotranscobalamin - holoTC) is the biologically active fraction of B12 which is required for intracellular metabolism.
Research suggests that Active B12 may be the earliest marker of vitamin B12 depletion. Moreover, unlike Total B12, Active B12 is believed to be a suitable marker to test during pregnancy.
Homocysteine is an amino acid. An elevated level of homocysteine is often the result of low levels of vitamin B12 and folate. Testing for homocysteine levels can therefore be a useful indicator in further investigating a B12 deficiency. Elevated levels are also considered a risk factor for heart disease, Alzheimer’s disease and cancer.
Elevated levels of methylmalonic acid (MMA) in the blood indicate deficiency of B12 or poor utilisation of vitamin B12 by the body's cells. MMA is considered the most representative marker of metabolic vitamin B12 status.
The Fedosov Factor is a combined indicator of B12 status, previously known as “wellness score”. We calculate this using a set of formulas which combine results from four different markers of vitamin B12 status and adjust for your age and folate status.
The reference combinations were derived from a large database of patients following mathematical modelling (Fedosov SN, et al. Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points. Clin Chem Lab Med 2015;53:1215–25.).
Who is this panel for?
This test is for individuals that want a more comprehensive health check for common nutrient deficiencies and are curious about the status of some of the less commonly measured vitamins. Vitamin D deficiency is very common in the UK, especially in the winter months, due to lack of exposure to the sun. Age is a factor in B12, folate, iron deficiency, as well as pernicious anaemia and conditions such as Crohn's disease. Those that restrict their diet, such as vegetarians and vegans, may also be more likely to develop deficiencies.This comprehensive nutrient deficiency test will provide details of the vitamin levels for commonly tested vitamins and those vitamins rarely tested.
Symptoms of B12, folate, and iron deficiency include fatigue, lethargy, breathlessness, feeling faint, headaches, heart palpitations, tinnitus and weight loss. Symptoms of B12 deficiency may also include pale yellow tinged skin, a sore and red tongue, mouth ulcers, depression and pins and needles.
Further iron deficiency symptoms, though less common, include headaches, tinnitus, an altered sense of taste, feeling itchy, a sore or abnormally smooth tongue, hair loss, difficulty swallowing, ulcers on the corners of your mouth and spoon shaped nails.
* Turnaround time measured from when blood sample is accepted in to the Viapath laboratory and does not include weekends or bank holidays.
How It Works
Choose a test panel
Customers are able to select from our ever-growing range of nutritional laboratory tests without a clinician/physician’s referral.
Have your blood collected
Choose to either have your blood taken at the Blood Test Centre at St Thomas’ Hospital in London, or receive a postal pack and have blood drawn by a qualified professional in a clinic of your choice.
Access your report online
Log in to your secure Viapath Nutris account to access your laboratory report with commentary from a registered healthcare scientist.